Epitopes of carcinoembryonic antigen (CEA) defined by monoclonal antibodies
نویسندگان
چکیده
منابع مشابه
Epitopes of carcinoembryonic antigen defined by monoclonal antibodies prepared from mice immunized with purified carcinoembryonic antigen or HCT-8R cells.
A library of 18 monoclonal antibodies (MAbs) reactive with purified carcinoembryonic antigen (CEA) has been prepared. The specificity of these MAbs was tested and they have been separated into nine subgroups, each recognizing a different region of the CEA molecule. Seven MAbs from four of the groups also react with the nonspecific cross-reacting antigen. Some of the MAbs are directed against co...
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The carcinoembryonic antigen (CEA) domain specificities of a library of monoclonal anti-CEA antibodies were determined to investigate the mechanisms of homophilic binding involved in CEA-mediated intercellular adhesion. Using an indirect immunofluorescence cell surface staining technique, the reactivities of these antibodies were tested systematically on Chinese hamster ovary cells stably trans...
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متن کاملSpecificity of Anti-Carcinoembryonic Antigen Monoclonal Antibodies and Their Effects on CEA-mediated Adhesion1
The carcinoembryonic antigen (CEA) domain specificities of a library of monoclonal anti-CEA antibodies were determined to investigate the mechanisms of homophilic binding involved in CEA-mediated intercellu lar adhesion. Using an indirect immunofluorescence cell surface staining technique, the reactivities of these antibodies were tested systematically on Chinese hamster ovary cells stably tran...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1988
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1988.34